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Conversely, levels of the catabolic (muscle-wasting) hormone cortisol begin to creep up in the middle of the night and stay elevated into the morning hoursas an adrenal gland spasms to release cortisol and adrenaline in an attempt to help regulate the energy levels in the body. The two processes – cortisol release and adrenal gland spasms to release cortisol – are both physiological response to stress and in both cases are highly adaptive to the body's need to maintain a constant state of energy. However, the two processes can easily be triggered or reactivated by any variety of stimuli. When stress is excessive enough, such as during a work-related setback, cortisol release can spike and spasm on its own, but when over stimulated, the spike is often a short and brief one, while adrenal gland spasms can quickly result in intense fatigue. The same phenomenon can have profound and long lasting effects on the person who uses it and the society in which they live. In fact, cortisol levels during intense emotional highs are a precursor to major depression, and for those with ADHD, their stress levels during these times can make it difficult to focus, making it difficult to complete tasks. These types of chronic, overstimulated reactions to stimuli create a vicious cycle in which the body and their minds begin to misfire and suffer from the physical and psychological consequences. 2. People's levels of anxiety and depression become amplified when they are in the grip of intense stress, such as following an exam. Treatment to reverse the effects of extreme stress is best done once cortisol levels are stable at a moderate (but not excessive) level. However, once levels of cortisol begin to rise, these conditions persist until the level of stress drops and a person regains optimal health. The fact that elevated levels of cortisol can cause a variety of long-term physiological complications (such as a drop in immune function) helps explain why it is one of the most problematic stress levels to tackle. 3. The stressor becomes more intense the more your body is exposed to it. Cortisol levels typically tend to rise when stressors such as stress, accidents, and other circumstances become more prominent. For example, when your body gets involved in an intense race or competition, cortisol levels often go up since adrenal glands are stimulated to release cortisol and adrenaline in an attempt to maintain the same level of blood flow to the muscle as they are during the race, and to maintain vital cells and structures. 4. The stressor is harder to deal with during a long vacation. When your muscles have been exhausted at work, you tend to Related Article: